clinical studies

How close are we to Artificial Intelligence and Machine Learning being utilised in every day work?

Artificial Intelligence Blog

AI is the current buzzword that we are all hearing on a daily basis, whether it is in a news article or at a conference, however understanding the implications of this technology, in the short, medium and long term is important to give it some context in relation to our daily work lives. Sarah Bennight, Director of Marketing at Stericycle Communication Solutions is quoted as saying ‘AI is everywhere. Every vendor seems to tout it, and every conference is filled with talk of everything AI. Folks tend to think that you throw in AI, and your paper gets published, your company gets funded, your product gets sold, and your customers’ interests get peaked. And therein lies the problem.

80% of Health executives agree that within the next 2 years, AI will work next to humans in their organisation, as a coworker, collaborator and trusted advisor, however 81% agree that organisations are not prepared to face the societal and liability issues that will require them to explain their AI-based actions and decisions, should issues arise (Accenture, Digital Health Tech Vision 2018).

To me, this sounds like ‘we know it’s coming, we just aren’t sure how we will handle it’, and that is probably true of many challenges we face on a daily basis. We have a vague idea of what is coming up in the near future, but it takes time and effort to dissect that into the day to day business of running an organisation.

One challenge that we have seen here in the Clinical Informatics Research Unit is around data quality, or often the lack of it. We have a team who work with hospitals to extract clinical data sets from Electronic Health Records and merge that with other datasets, in order to allow clinicians to link and query the information, for either research or audit purpose. A huge amount of time is invested in cleaning that data, identifying any outliers in it and addressing them. Even the question of ‘what is an outlier’ needs to be defined up front. Arm measurements can be recorded in CM’s, MM’s or inches (we’ve seen all 3). Alternatively some data points are clearly arbitrary, for example patients who are 1 cm tall and weigh 1 kg, the result of which can often be tracked back to the field being compulsory for someone to complete in the EHR, who doesn’t have that information to hand at the point of completion and just enters those values to reach the next page. Dr Sachin Jain, former CMIO at Merck and now CEO of CareMore Health explain to Forbes in January 2019 ‘The first thing we’ve learned is the importance of having outstanding data to actually base your Machine Learning on. In our own shop, we’ve been working on a few big projects, and we’ve had to spend most of the time just cleaning the data sets before you can even run the algorithm. That’s taken us years just to clean the datasets. I think people underestimate how little clean data there is out there, and how hard it is to clean and link the data.

Bias is another challenge inherent in machine learning. The algorithm will only be as good as the data model that it is trained on, and ensuring that is a big challenge. A worrying quote from Dr Dhruv Khullar in the New York Times said ‘In medicine, unchecked A.I. could create self-fulfilling prophesies that confirm our pre-existing biases, especially when used for conditions with complex trade-offs and high degrees of uncertainty. If, for example, poorer patients do worse after organ transplantation or after receiving chemotherapy for end-stage cancer, machine learning algorithms may conclude such patients are less likely to benefit from further treatment — and recommend against it.

Despite the challenges that lay ahead with AI and ML, the excitement surrounding it is unlikely to go away, and in the future, understanding the algorithms that govern decisions made by computers will be a core component of the governance of any organisation utilising them.

Certainly from an EDGE perspective, I think I am quite safe to say that we will monitor the developments in these technologies over time, and when, or most importantly if the time is right, implement them in a careful and considered manner.

In the meantime, if you want to have a play around with Machine Learning, there is an interesting model that you can use, provided by Microsoft, on the dataset of passengers on the fateful Titanic Voyage that can be found here

Using EDGE to manage a complex primary care study

My name is Randeep Basra and I am a Clinical Studies Officer for the Clinical Research Network in North West London. I am part of the delivery team that helps with the setup and support at primary care sites and recruitment of participants for research projects that I am assigned to work on.

One of the projects currently in progress is iHealth-T2D, a multicentre, cluster randomised clinic trial on type 2 diabetes in the South Asian population. The study looks to provide evidence that the implementation of lifestyle modifications and health promotion is clinically effective in reducing the onset of type 2 diabetes in South Asians with central obesity or pre-diabetes compared to usual care. Managing the study has brought on some complex and challenging situations in terms of project management, where communication, organisation and team work has been key to the success we have experienced so far.

This has been helped significantly by the use of EDGE. In the early stages, large amounts of information about the study was kept in a number of places that were not so easy to access and were becoming difficult to manage by the team as a whole. An example of such information was the staff involved and their contact details, information about clinics being run at GP practices and patients recruited, just to name a few. When hearing about EDGE, we felt it could work to solve these issues.

Since then, we haven’t looked back. Once the process of uploading all the information to EDGE had taken place, we found it straightforward to access and the layout easy to navigate. We are able to effortlessly store different pieces of information about the project or primary care sites in one place that everyone can see. For example, I can find a particular recruiting site in a couple of clicks and can access information on how many patients were contacted from a particular site and on what date, when screening clinics are running and how many participants have been recruited so far. The outcome is that everyone is able to look at and maintain up-to-date information about the study from a single place from almost any location at any time.

Knowing that I can add users and have the contact details of any member of staff from any of the 50+ GP practices taking part is reassuring and allows a smooth stream of communication with everyone involved. Personally, the “notes” section is a highlight for me, as being able to communicate updates about an individual site for everyone to see in a free-text box saves time on administration and permits flexibility depending on what information can be stored here. Although it is not necessary to upload patient information to EDGE for our team, I have found using anonymous codes for each patient recruited at GP practices has been a safe and fool-proof way for me to keep an accurate record of how many participants are engaged with the study. Last, but certainly not least, the “project attribute reports” have been wonderful when requiring a snapshot of the study for team meetings and to assess data quality.

This hasn’t just been useful for me the delivery team – other staff who support the delivery team have found it a great way to pull off information from the system when it comes to arranging financial payments or tracking recruitment. In fact, this study was the first we have tried to store financial information on and while this is work in progress, it has been very useful so far. In this way, the whole team can be singing from the same hymn sheet without the need for endless spreadsheets and hard-to-follow email trails.

We would like to give a special thanks to Kaatje and Sean for all the support we have had in making this system work well for the project. We feel the adaptability and brains of the system, as well as the people behind it, are what make it work for us.

Here is a shot of the team who have all been involved in delivering the study.

Here is a shot of the team who have all been involved in delivering the study.

Post by Randeep Basra, Clinical Studies Officer
CRN North West London
randeep.basra@nihr.ac.uk

Read an article from us

communication highway.JPG

You can find an article from our director James Batchelor in this months International Clinical Trials magazine. The title of the article is 'Strength through Collaboration', where James promotes research teams coordinating both nationally and internationally, in safely changing routine standards of clinical care to improve patient quality of life. 

This piece can be found here and has been taken from International Clinical Trials May 2017, pages 24-26 © Samedan Ltd

Visit the contents page of the current issue of PMPS here